ABSTRACT
Areca catechu ranks the first of China's precious "four southern medicines", with a history of more than 1 800 years of medicinal use and extensive clinical application. The pharmacological effects of A. catechu mainly focus on insect repellent, anti-tumor, anti-aging, anti-atherosclerosis and the effects on digestive system and nervous system. In recent years, safety problems such as oral cancer caused by consumption of A. catechu have been frequently reported, and the main chemical components of both medicinal and edible A. catechu are arecoline, so the clinical safety of medicinal A. catechu has been questioned. Based on the chemical composition, this paper analyzes the pharmacological and toxicological characteristics of A. catechu, discusses the points for attention in clinical application, in order to provide a reference basis for the clinical safe and rational use of A. catechu.
ABSTRACT
Skin itching is a subjective sensation that causes the desire to scratch. It is one of the most common clinical symptoms at department of dermatology, even the only complaint of dermatological patients, which seriously affects the quality life of patients. Therefore, based on the software of traditional Chinese medicine inheritance auxiliary platform, association rules and complex system entropy clustering were adopted to collect and analyze Zhang Bing's prescriptions for skin itching, and get the drug use frequency and the relationship between drugs. Based on that, we could conclude the experience for skin itching. A total of 147 prescriptions were collected, 20 drugs with a frequency of 34 or more and 20 high-frequency drug combinations were analyzed, and 14 core combinations and 7 new prescriptions were excavated. The high-frequency drugs included Kochiae Fructus, Dictamni Cortex, Mori Cortex. The high-frequency drug combinations included "Kochiae Fructus-Dictamni Cortex" "Angelicae Dahuricae Radix-Chuanxiong Rhizoma" "Paeoniae Radix Rubra-Paeoniae Radix Alba", and the core combinations included "Schizonepetae Herba-Saposhnikoviae Radix-Cinnamomi Ramulus" "Arctii Fructus-Cicadae Periostracum-Houttuyniae Herba" "Ghrysanthemi Indici Flos-Kochiae Fructus-Dictamni Cortex", and new formulations include "Schizonepetae Herba, Saposhnikoviae Radix, Cinnamomi Ramulus, Clematidis Radix et Rhizoma, Tribuli Fructus, Dictamni Cortex", "Phellodendri Chinensis Coritex, Lonicerae Japonicae Flos, Atractylodis Rhizoma, Ghrysanthemi Indici Flos, Kochiae Fructus, Dictamni Cortex" "Arctii Fructus, Cicadae Periostracum, Houttuyniae Herba, Trichosanthis Fructus". The result of this research shows that Professor Zhang Bing's experience in the treatment of skin itching is mainly to dispelling wind and arresting itching, clearing heat and drying dampness.
Subject(s)
Humans , Data Mining , Drug Combinations , Drugs, Chinese Herbal , Therapeutic Uses , Medicine, Chinese Traditional , Pruritus , Drug Therapy , SoftwareABSTRACT
“Decoction wrapped” is one of the characteristics of the special decoction of Chinese material medica. However, Some people have a certain misunderstanding or lack of basic knowledge about Chinese material medica for “decoction wrapped”, leading to the bad clinical effect or even side effects because of improper decoction. This study attempts to analyze the causes and attentions of Chinese materia medica for decocting based on multiple literatures, and put forward exploratory thinking on Methods: for decoction wrapped in order to provide scientific evidence for promoting clinical rational decoction for Chinese materia medica.
ABSTRACT
"Guiding herbs" is one of the characteristics of the special way of taking Chinese materia medica (CMM). However, some people have misunderstanding or lack of basic knowledge about how to choose the guiding herbs and its effect, leading to the poor clinical effect or even toxic effects because of improper decoction. This study attempts to analyze the action of the common guiding herbs in the Chinese Pharmacopoeia (2015 edition) from the perspective of reducing toxicity and increasing efficacy, returning drug to its channels, and put forward exploratory thinking on how to choose the guiding herbs to provide scientific evidence for promoting the rational use of drugs in clinic.
ABSTRACT
"Decoction first" is one of the characteristics of the special decoction of Chinese materia medica (CMM). However, some people have misunderstanding or lack of basic knowledge about the CMM for decoction first leading to the poor cruative effect or even toxic effects because of improper decoction. This study attempts to analyze the causes of CMM for decocting first from the perspective of reducing toxicity and increasing efficacy, discuss its matters needing attention from the point of view of the effect of decoction time and crushing degree on the decoction first based on ancient and modern literature, and put forward exploratory thinking on methods for decocting first in order to provide scientific evidence for promoting clinical rational decoction for CMM.
ABSTRACT
“Decoction later” is one characteristic feature of the special decoction of Chinese materia medica (CMM). However, some patients have misunderstanding or lack of basic knowledge about CMM for “decoction later” leading to the bad clinical effect or even toxic effects because of inappropriate decoction. This study attempts to analyze the causes of CMM for decoction later based on ancient and modern literatures, and put forward exploratory thinking on methods for decoction later in order to provide scientific evidence for promoting clinical rational drug use for decoction later of CMM.
ABSTRACT
Sophorae Tonkinensis Radix et Rhizoma is known as the important drug for treating sore throat and is widely used in clinic. Because of the coexisting of its efficacy and poison, Sophorae Tonkinensis Radix et Rhizoma often leads to a series of safety problems in the clinical application process. In this study, we attempt to analyze the ultimate cause of the toxicity of Sophorae Tonkinensis Radix et Rhizoma by reviewing nearly 20 years of literature, discuss the substance of its efficacy/toxicity from the point of view of chemical composition, and put forward exploratory thinking on its clinical rational application.
ABSTRACT
Asari Radix et Rhizoma has been used for more than 2000 years with wide application in medicine. In recent years, there are many poisoning cases of Asari Radix et Rhizoma being reported in clinic, the rational application in clinic of Asarum Radix et Rhizoma has been widely concerned due to its poisonous componets of safrole and aristolochic acid. The present paper traces the historical evolution of Asari Radix et Rhizoma through accessing Web of Science and multiple databases for biomedicinal sciences, and analyzes the characteristics of its toxic reaction, and discusses the matters needing attention in its rational application from the perspective of chemical composition, so as to promote the safe and reasonable application of Asari Radix et Rhizoma.
ABSTRACT
Gentianae Macrophyllae Radix, widely distributed in northwest districts of China, is rich in resources, and is a kind of medicinal plants with great utilization value. From the phytochemical view, the second metabolites such as secoiridoids, iridoids, lignans, flavonoids, and triterpenoids had been reported from this species. Its pharmacological research mainly focused on the anti- inflammatory and analgesic, hepatoprotective, hypotensive, antiviral, and antineoplastic activities. The present paper reviews the phytochemistry and biological activities of Gentianae Macrophyllae Radix through accessing Web of Science and multiple databases for biomedical sciences.
ABSTRACT
Sixty SD male rats were randomly divided into normal group, model group, benzbromarone group(20 mg•kg⁻¹•d⁻¹), chicory extract high dose, middle dose and low dose groups (5, 7.5, 10 g•kg⁻¹•d⁻¹). The rats in normal group were given with water, and the rats in other groups were given with 10% fructose solution to establish hyperuricemia models. All the rats were sacrificed on the 42th day. Then their serum uric acid(SUA), serum creatinine(CRE), urea nitrogen(BUN) and urinary uric acid(UUA) levels were detected to calculate the clearance rate of uric acid in kidney(CUA). Meanwhile, the protein and gene expression levels of renal glucose transporter family member 9(Glut9) were detected by immunohistochemical and Real-time quantitative reverse transcription-polymerase chain reaction(RT-qPCR) methods. The effects of Chinese herb chicory extract on expression of renal Glut9 and decreasing uric acid were explored in this study, and the results showed that chicory extract could reduce SUA level in rats with hyperuricemia, increase renal CUA, decrease the protein expression of renal Glut9, inhibit uric acid re-absorption in kidney, and thus promote renal uric acid excretion.
ABSTRACT
Fraxini Cortex is widely distributed in China and rich in resources, and is a kind of medicinal plants with great utilization value. From the phytochemical view, the secondary metabolites such as coumarins, lignans, secoiridoids, phenylethanoids, flavonoids, phenolic acids, and triterpenoids had been reported from this species. Its pharmacological research mainly focused on the antibacterial, antiphlogistic, anti-oxidative, lowing-uric acid, diuretic, and antineoplastic activities. The present paper reviews the phytochemistry and biological activities of Fraxini Cortex through accessing Web of Science and multiple databases for biomedicinal sciences.
ABSTRACT
Human xanthine oxidase is considered to be a target for therapy of hyperuricemia. Cichorium intybus is a Chinese plant medicine which widely used in Xinjiang against various diseases. In order to screen the inhibitors of xanthine oxidase from C. intybus and to explore main pharmacological actions of cichory a compound collection of C. intybus was built via consulting related references about chemical research on cichory. The three-dimensional crystal structure of xanthine oxidase (PDB code: 1N5X) from Protein Data Bank was downloaded.. Autodock 4.2 was employed to screen the inhibitors of xanthine oxidase from cichory 70 compounds were found to possess quite low binding free energy comparing with TEI (febuxostat). C. intybus contains constituents possessing potential inhibitive activity against xanthine oxidase. It can explain the main pharmacological actions of cichory which can significantly lower the level of serum uric acid.